B. He has a longstanding history of vaping THC and tobacco products
Discussion
This CT scan demonstrates ground glass opacification with relative
sparing of the subpleural spaces. Of the answer choices, this is most
consistent with e-cigarette or vaping product use associated lung injury
(EVALI). The patient acknowledges frequent and chronic vaping product
use. He started vaping when he was nine years old and continues to vape
both THC oils and tobacco products daily. During his hospitalization,
the patient required transfer to the PICU for bilevel noninvasive
respiratory support. Additionally, his course was complicated by
pneumomediastinum, bilateral pneumothoraces and subcutaneous emphysema,
all managed medically. He responded well to a course of systemic
steroids and was discharged home on room air with close pulmonary
outpatient follow-up.
Pet parakeets may be associated with an acute hypersensitivity
pneumonitis. Hypersensitivity pneumonitis presents radiologically with
upper and middle lobe predominant ground-glass opacities with possible
mosaic attenuation and poorly defined centrilobular nodules (Answer A is
incorrect). Exploring caves may raise suspicion for acute
histoplasmosis. Typically, chest imaging will identify consolidation
similar to bacterial pneumonia and may show healing histoplasmomas or
nodules with central calcification (Answer C is incorrect). Ingestion of
undercooked pork is associated with pulmonary toxoplasmosis. Pulmonary
toxoplasmosis can manifest as interstitial pneumonia/diffuse alveolar
damage or necrotizing pneumonia (Answer D is incorrect). This is
typically seen in immunocompromised hosts. Subpleural sparing is not
classically associated with any of the above conditions.
Use of e-cigarettes in the U.S. has increased from approximately 7
million users in 2011 to 41 million users in 2018. Users of e-cigarettes
can inhale high concentrations of propylene glycol, glycerol, volatile
organic compounds, heavy metals and ultrafine particulates. The first
outbreak of EVALI was first reported in August of 2019 in Wisconsin.
From August 2019 to February 2020 there were 2807 confirmed cases and 68
deaths. 82% of patients hospitalized with EVALI reported use of a
product with THC and vitamin E acetate. The CDC has since published a
case definition including the following:
- Use of an e-cigarette within 90 days before symptom onset
- Presence of pulmonary infiltrate such as opacities on plain film chest radiograph or ground glass opacities on chest CT
- No evidence of infection identified via culture or PCR
- No alternative plausible diagnoses
Patients with EVALI often have gradual onset of cough, chest pain,
shortness of breath, abdominal pain, nausea, vomiting, diarrhea,
fatigue, fever and tachycardia. Laboratory results often demonstrate
leukocytosis with neutrophil predominance, elevated inflammatory
markers, and elevated transaminases.
Chest imaging, apart from subpleural sparing, is often non-specific.
Studies have shown that most patients have chest CT imaging with
ground-glass opacification (96-100%). Septal thickening can be seen in
14-29%, consolidation in 42-64%, and subpleural sparing in 45-79% of
patients.
The primary treatments may include antibiotics to treat superimposed
infections and corticosteroids to treat lung inflammation. However,
there is no conclusive studies to date demonstrating steroid efficacy.
Long-term effects of EVALI on lung health are not yet known.
References
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