Franziska Rosser, MD, MPH, and Juan Celedon, MD, will be presenting their newly published work where their group conducted a meta-analysis of transcriptome-wide association studies (TWAS) of long-term PM2.5 exposure in nasal epithelium from 321 youth with asthma aged 6-20 years from three cohorts, mostly from minoritized populations. They discovered that long-term PM2.5 exposure was associated with differences in 3 genes: CLCA1, SYCP2, and CYP2A6. CLCA1 upregulation was also associated with positive allergen-specific IgE, and increased blood eosinophils and total IgE. They concluded that PM2.5 exposure might deregulate airway epithelial CLCA1 expression with effects on T2-high biomarkers.
Javier Perez Garcia, PhD, will be moderating this journal club. We will be joined by the first author, Franziska Rosser, MD, MPH, as well as discussion panelists Juan Celedon, MD, senior author, University of Pittsburgh and UPMC Children's Hospital of Pittsburgh, Andres Cardenas, PhD, Stanford University, and Max Seibold, PhD, National Jewish Health and University of Colorado- AMC.