In this webinar, Nathan Salomonis, PhD, from Cincinnati Children's Hospital will review bioinformatics and genomics resources provided through the LungMAP.net website. Dr. Salomonis is the co-PI of the LungMAP Data Coordination Center (DCC). The LungMAP research consortium, now in third phase, works to understanding of the regulatory mechanisms that govern chronic, congenital, and infectious lung diseases, lung injury, and other lung disease pathologies. The DCC works to achieve these objectives through a series of outward facing open-access research portals hosted in diverse research clouds. Research portals hosted by LungMAP include dynamic data browsers for single-cell genomics (Azimuth, ShinyCell, ToppCell, Morpheus), epigenomics (JBrowse), spatial imaging/transcriptomics (WebAtlas, OMERO) and cell nomenclature (CellCards, CellRef, RedCap). The source datasets for these different tools, including raw, processed data and structured metadata, are accessible through a dedicated LungMAP Dataset Browser, which is connected to the cloud-native Terra.bio platform for on-demand interactive re-analysis of data ingested by LungMAP.
In this webinar, the major components of the LungMAP ecosystem will be explored and demonstrated. A major highlight of this presentation, will be a new AI-based platform called LungChat that enables fast realtime analyses of over 40 lung genomics datasets spanning 15 diseases and fetal development, single-cell and spatial transcriptomics datasets. LungChat is a multi-agent large-language model-based architecture, designed to address diverse research questions. We encourage questions throughout the presentation with a discussion to follow.
LungMAP Portal Ecosystem: Systems-level Exploration of the Lung