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Assembly

Under Pressure

Authors
Rajendraprasad, Sanu S1
Gary, Phillip J1
Wiley, Brandon M2
Park, John G1
1Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN.
2Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.


Case

A 75-year-old female with a history of multiple myeloma in remission, IgG deficiency, OSA, paroxysmal atrial fibrillation not on anticoagulation was admitted for COVID-19 pneumonia. She was admitted to a monitored unit, placed on a high-flow nasal cannula, and received remdesivir and dexamethasone, and antibiotics for urinary tract infection. Several hours after admission, she decompensated and was transferred to the medical intensive care unit where she underwent endotracheal intubation for tachypnea and worsening hypoxia. Following intubation, she manifested shock requiring multiple vasoactive medications. Laboratory findings were notable for lactate > 12 and PaO2:FiO2 ratio of 80. ECG revealed findings of S1Q3T3 and T wave inversion in lead V1 & V2.

Bedside point-of-care ultrasound (POCUS) assessment of the heart showed:

Parasternal long axis
Video 1. Parasternal long axis
Parasternal short axis
Video 2. Parasternal short axis
Severe RV dilation, flattening of the interventricular septum during systole and diastole, and compromised LV filling.
Apical 4 chamber
Video 3. Apical 4 chamber
Dilated RV with McConnell sign - paradoxical RV apical “hyperkinesis” in the setting of RV global hypokinesis

Question

With the above ECG and POCUS findings, what would be your immediate next step?

A. Thrombolytic therapy
B. Interventional Radiology (IR) guided thrombectomy
C. Restart broad-spectrum antibiotics
D. Emergent cardiac catheterization

Answer